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MATERIAL AND METHODS Materials Antibodies against insulin, GLP-1, GLP-1R, cluster of differentiation 31 (CD31), and Ki67 were from Abcam (Cambridge, MA)

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The report noted that individuals with clinical obesity should receive timely, evidence-based treatment to improve or remit symptoms and prevent further complications

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Random-effects models were applied, and sensitivity analyses examined result stability

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doi: 10.1016/S2213-8587(18)30104-9 65 Van Der Aart-Van Der BeekA

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In piecewise models, patients beginning GLP-1RA treatment had an HR of 1.75 and 3.30 compared to SU and SGLT2i users, respectively

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Diarrhea, vomiting, constipation, abdominal pain, and decreased appetite also occur in a meaningful minority of patients on both drugs

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