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However, as with any relatively novel therapy, possible consequences of indefinite therapy will only be revealed with time

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Compounded versions in pill form or mixed with other ingredients havent undergone rigorous trials

Perez cautions that "most people tolerate probiotics fine, but they still aren't risk-free." He notes that people with irritable bowel syndrome (IBS) or small intestinal bacterial overgrowth (SIBO), or who are immunocompromised, should be cautious with any probiotic and only take one under the guidance of a health care professional

It is also important for understanding the effect(s) of drug therapy that targets pathways and receptors that are shared between organs

Given the biological latency of carcinogenesis, longer-term studies are required to determine whether these signals persist or translate into clinically meaningful reductions in cancer risk