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Other Possible Serious or Concerning Side Effects Although rare, some studies have reported more serious or unusual adverse events, including: Cardiac arrhythmia Elevated liver enzymes Acute pancreatitis (rare cases) Abnormal skin sensations (dysesthesia) in some trials Because the drug affects several hormone pathways involved in metabolism, researchers say long-term safety data will be essential before approval

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While liraglutide improved spatial cognition, it also reduced astrocytes and microglia activity, ameliorated amount of A levels and mitochondrial dysfunction in cortical and hippocampal CA1 and CA3 regions, and prevented neuron loss by activating cAMP/PKA pathway in brain of 5FAD mice (188, 208)

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