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Our review provides insights into the interplay of lifestyle factors, genetic predispositions, and the significant psychological and physiological burdens associated with managing these comorbid conditions

The medication has been used safely in millions of patients over six decades, providing physicians with extensive data on long-term outcomes and rare adverse effects

DOI: 10.1056/NEJMoa2505669, Zhang, J., Wei, J., Lai, W., et al

While not common, some people experience significant psychological effects on semaglutide

The larger bore allows smooth fluid transfer

The risk of generalised skin reactions, such as widespread rash or urticaria, appears to be low based on current evidence, though trial populations may not fully reflect the diversity of patients who would use the medication in routine clinical practice