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This would be most likely if retatrutide severely suppresses your appetite or if gastrointestinal issues such as nausea interfere with eating

2024;36:A4-86

But for a significant percentage of users, tirzepatide ultimately improves energy levels

Metabolic Syndrome: A post hoc analysis revealed that patients achieving 15% weight loss had a significant decrease in the prevalence of metabolic syndrome, from 8091% at baseline to 2028% at Week 40/52

Studies show that much of the weight lost on GLP-1 drugs can be regained after stopping them if no lasting lifestyle changes are in place