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doi: 10.1038/s42255-021-00369-9
Knowler WC, Fowler SE, Hamman RF, et al

Upon secretion, for example in response to food intake, GLP-1 contributes to regulating blood glucose levels, mainly by stimulating insulin secretion and inhibiting glucagon secretion from the pancreas

Belly weight and increased stomach circumference

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This instability often necessitates frequent dosing and can lead to unfavorable pharmacokinetic profiles and potential immunogenic responses from degraded fragments
