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Both tirzepatide (since 2022) and semaglutide (since 2024) were placed on the shortage list, prompting a surge in sales of compounded alternatives

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Structured resistance training (24/week) Adequate protein intake (1.21.6 g/kg/day) Micronutrient optimization (Vitamin D, B12, Omega-3) Avoiding extreme caloric restriction Theres also growing scientific interest in myostatin inhibitors such as Bimagrumab which have shown the ability to preserve lean mass and enhance fat loss when combined with GLP-1 therapies