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In the Phase 2 T2D trial, exploratory analyses showed significant reductions in liver fat content with retatrutide

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When one drug inhibits CYP enzymes responsible for metabolising another CNS drug, plasma and brain concentrations may rise, increasing the risk of toxicity

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It is primarily used as subcutaneous injections and oral formulations [6,7]

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All insulins, including Toujeo, Lantus, Tresiba, Levemir, Humalog, and NovoLog, are insulin products, not GLP-1 medications

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The actual future market size will likely be highly impacted by whether GLP-1RAs end up being used as longer-term treatments for individuals and how costs and pricing evolve over time

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Comparator Selection : Many trials use placebo comparisons rather than active comparators, limiting understanding of relative effectiveness compared to existing obesity treatments

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