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These effects were coupled to an amelioration in lipid metabolism and hepatic steatosis, which markedly exceeded the effect of single GLP-1RA treatment ( Oxyntomodulin, a gut-derived peptide hormone, activates both the GLP-1R and the GCGR, although, with reduced affinity compared to GLP-1 and glucagon, respectively

GLP-1RAs effects are relevant to MS, with potential to modulate inflammation, promote remyelination, and to stabilize the BBB

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They bind to the same receptors but resist the enzymatic breakdown (by DPP-4) that rapidly degrades natural GLP-1

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