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[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Meloni A.R., et al

How Do GLP-1 Agonists Regulate Appetite and Blood Sugar

Rather than targeting appetite or insulin signaling, this peptide is a modified fragment of human growth hormone, specifically amino acids 176 through 191, that directly stimulates fat metabolism without the broader effects of full growth hormone therapy

your titration is one of the inputs

Oral medications do not require refrigeration, making them easier to transport and store at home

Carlat Verdict: To prevent metabolic side effects when beginning an antipsychotic, start with metformin, but consider a GLP-1 RA for patients who have already been on antipsychotics for a while with a BMI 30 kg/m 2 (or 27 kg/m 2 and obesity-related health problems)
