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FDA has specifically flagged concerns with compounded injectable GLP-1 products, including: Nausea, vomiting, diarrhea, abdominal pain, and constipation Excessive dosing tied to titration mistakes, some serious enough to require hospitalization Concentration, measurement, labeling, and dosing considerations a mass-manufactured branded pen doesn't have in the same way A licensed provider needs to review your full medical history, current medications, and complete medication-specific risk information with you before treatment starts - this section is a prompt to have that conversation, not a substitute for it

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adults (roughly 1 in 8) report having taken a GLP-1 drug at some point

Effects of renal insufficiency on the pharmacokinetics of sitagliptin, a dipeptidyl peptidase-4 inhibitor