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Tanaka, Oral semaglutide induces loss of body fat mass without affecting muscle mass in patients with type 2 diabetes

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In terms of mitochondrial function, GLP-1RAs act through multiple pathways: first, stimulating mitochondrial biogenesis via the AMPK signaling pathway to boost both the number and functionality of mitochondria (93)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 282.Finan B., Yang B., Ottaway N., Smiley D.L., Ma T., Clemmensen C., Chabenne J., Zhang L., Habegger K.M., Fischer K., et al

Although renal GLP-1 receptors have been identified, their exact localization and physiological role are incompletely understood