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Diabetes 65:11901195 Ferrannini E, Mark M, Mayoux E (2016b) CV protection in the EMPA-REG OUTCOME trial: a thrifty substrate hypothesis
GLP-1s can reduce total body fat and weight, but targeted reduction of lipedema fat is unproven
Figure 2: Diabetes and Incretin effect
These results warrant further translational exploration of GLP-1R agonists, particularly in individuals for whom metabolic dysregulation and addiction vulnerability converge
Wegovy: Patients prioritizing cardiovascular protection or requiring pediatric use
