glp 1 comorbidities Breakthrough of the Year: GLP-1 Agonists and Cardiometabolic Disease Incretin-based medications—developed based on the

doi: 10.1056/NEJMoa1506930 259 DoehnerWErdmannECairnsRClarkALDormandyJAFerranniniEet al

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Discovered through a structure-based drug design (SBDD) strategy combined with systematic physicochemical property optimisation, IBI3032 has shown better PK and physicochemical properties compared to similar compounds

J Drug Target