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The mechanism by which metformin acts by regulating the gut microbiota needs to be further clarified

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Other studies have reported effects on overall growth of the pancreas (as opposed to islet growth) or evidence of increased exocrine mitogenesis

2015;308(8):F86777

Symptoms may also appear after increasing the dosage because the digestive system must adjust again

Philis-Tsimikas A, Billings LK, Busch R, Portillo CM, Sahay R, Halladin N, et al