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Microorganisms in the intestines can pass through the intestinal barrier and enter the portal vein lumen when the permeability of the intestinal barrier decreases

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3.4 GIPR/GLP-1R Dual-Agonists The observation that weight loss in DIO mice is enhanced by co-therapy with GIPR and GLP-1R agonists (126) has resulted in the development of unimolecular GLP-1R/GIPR dual-agonist peptides (82, 126)

At this stage, the evidence should be viewed as early-phase research , not confirmed treatment outcomes