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Severe obesity and diabetes insipidus in a patient with PCSK1 deficiency

Without resistance training, your body has no reason to maintain muscle mass during a caloric deficit

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Nutrition matters more when total food intake drops

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The more clinically relevant question is whether controlled glucagon receptor activation, when paired with GLP-1 and/or GIP receptor agonism, can shift glucagons metabolic impact from primarily hyperglycemic toward thermogenic, lipolytic, and hepatometabolic benefit