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Nat Neurosci 8:571578 Kristensen P, Judge ME, Thim L, et al (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin

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Mechanically, insulin mainly activates two signal pathways: insulin receptor (IR)-insulin receptor substrates (IRS)-phosphatidylinositol 3-kinase (PI3K)-protein kinase B (AKT) signal pathway (Pollak, 2008)

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