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The covariates were adjusted in the PSM model for a priori-identified potential confounders, such as age, sex, race/ethnicity, nicotine dependence, BMI, type 2 diabetes, hypertension, hyperlipidaemia, hypercholesterolaemia, chronic respiratory disease, chronic renal diseases, BP, chronic kidney disease, peripheral vascular diseases, diabetes-related microvascular complications, glomerular diseases, cirrhosis of the liver, osteoporosis, sleep apnoea, abnormal laboratory findings (HbA 1c , serum cholesterol, LDL-cholesterol, HDL-cholesterol and triacylglycerol [TG]) and intake of cardiovascular medications (Table 1)

That being said only 4.1 % of patients stopped the 4mg dose which is less than the placebo arm

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For some, these medications can have a really subtle effect on appetite and still lead to weight loss in time. 3

Chronic excessive dosing may lead to bone resorption increasing resulting in osteoporosis Thyroid hormones may lower the seizure threshold Adverse Effects Transient partial hair loss may occur during the first few months of therapy in children

We conducted a detailed subgroup analysis comparing different GLP-1 RA groups to non-GLP-1 RA users