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In a pre-specified secondary analysis of the SELECT trial, once-weekly subcutaneous semaglutide 2.4mg in patients with obesity was associated with a 22% reduction in the main 5-component kidney composite endpoint compared to patients on placebo.
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Whilst all GLP-1RAs use has increased, the largest change was seen in patients using tirzepatide and semaglutide ([figure 1B][1])
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