glp-1 agonist weight gain effects Agonists - What is it? GLP-1 Medications: Everything You Need
Description
Lengsfeld S, Burkard T, Meienberg A, Jeanloz N, Vukajlovic T, Bologna K, et al

and Germany

Nevertheless, there remains a paucity of research regarding the function of the GLP-1R signaling pathway in the modulation of other immune cell types, including DCs, B cells, and mast cells

That includes 11% that report using them specifically for weight loss as well as 11% who use GLP-1s to treat diabetes
In the meantime, the evidence supports GLP-1RAs as a strong alternative to metformin, especially in cases where weight loss is a primary treatment goal

With that context in mind, here are some of the reasons a provider may consider a lower starting dose for certain individuals
