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Estimated lifetime cardiovascular, kidney, and mortality benefits of combination treatment with SGLT2 inhibitors, GLP-1 receptor agonists, and nonsteroidal mra compared with conventional care in patients with type 2 diabetes and albuminuria

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This seemingly paradoxical outcome was possible because postabsorptive energy expenditure was dramatically increased with brain GLP-1 blockade, as indicated by increased insulin-sensitive glucose utilization in glycolytic muscle and white adipose tissue, as well as increased locomotor activity and cold-induced thermogenesis (16)

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