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The latter explanation, though less desirable and exciting from the perspective of therapeutic implications, is the simpler of the two, as it fits with what we already know about how these drugs impact metabolic health and how metabolic health impacts cardiovascular disease

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Given the increasing use of incretin-based therapies in younger individuals with obesity and metabolic disorders, future studies should investigate whether microbiota-related determinants of treatment response differ across developmental stages and age groups
It advised the public to refrain from them if an approved medication is available

In heart failure patients, there was a lack of changes in cardiac imaging parameters correlates with the lack of impact on outcomes among patients with pre-existing heart failure in major GLP-1 receptor agonist trials

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