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New England Journal of Medicine, 370(12), 1081-1083

Additionally, some patients experience mild dehydration or nutrient shifts during the initial adjustment period, which may contribute to low energy levels

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Ten years later, the first monoclonal antibody, natalizumab, was approved, followed by a third important landmark with the introduction of oral medications, initially fingolimod and then teriflunomide, dimethyl fumarate and cladribine

Wegovy, by contrast, is FDA-approved for chronic weight management in adults with obesity or overweight with weight-related conditions