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Activation of the GLP-1 receptor potentiates the synthesis and release of insulin from pancreatic beta-cells in a glucose-dependent manner

Zibotentan in combination with dapagliflozin compared with dapagliflozin in patients with chronic kidney disease (ZENITH-CKD): a multicentre, randomised, active-controlled, phase 2b, clinical trial

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It has also been shown that it can influence the proliferation and survival of cells and has a certain effect on the prognosis of some neoplastic diseases

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Instead, SGLT2is are more effective in the setting of HF and in patients with chronic kidney disease (with or without T2D) for the treatment and prevention of these conditions, whereas GLP-1RAs appear to remain more compelling in weight loss, glycemic control, and cardiovascular benefits in T2D patients [143]