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Hyperphagia in the placebo group worsened significantly

It takes about 12 weeks to reach the maintenance dose of 25mg

Gastrointestinal effects Beyond nausea, the full spectrum of GI side effects includes constipation, diarrhea, bloating, and abdominal discomfort

In early 2023, the American Academy of Pediatrics recommended that children and teens with obesity be evaluated early and treated aggressively, including with surgery and medication if warranted

Moreover, abnormalities associated with hypertension, such as insulin resistance and hyperlipidemia (high lipid levels), can be worsened by some anti-hypertensive medications

Metabolic improvements often begin within weeks, before significant weight loss occurs