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This is substantially less than the 3-15 grams used in oral supplementation studies, but the injectable route provides direct systemic delivery that bypasses gastrointestinal absorption losses

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We found that, at baseline, the BMI distribution differed between MC4R mutation carriers and noncarriers ( P = 0.036)

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Phase 2 data also showed meaningful reductions in fasting blood glucose, HbA1c, triglycerides, and waist circumference across dose groups [7]