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Important safety considerations include common adverse effects such as gastrointestinal symptoms (nausea, vomiting, diarrhea), which occur in 20-40% of patients but typically diminish with continued use

How Tirzepatide Dosing Begins and Progresses Most patients starting tirzepatide begin at a low initial dose, typically 2.5 mg weekly by injection

New England Journal of Medicine (2023) Phase 2 obesity results Rosenstock J, et al

Prices provided are for relative comparison purposes only and may not be a reflection of the actual cost of either drug at the time of purchase.

GLP1R agonists ameliorate peripheral nerve dysfunction and inflammation via p38 MAPK/NFkappaB signaling pathways in streptozotocininduced diabetic rats

A study of Australian sales data published in November found that since May 2020, total sales of these drugs in Australia increased almost 10-fold, reaching about half a million units each month in 2024/25, despite significant disruptions to access during shortages, with around 200,000 people now using them