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[23] By comparison, the placebo condition caused no changes except a 13% increase in triglycerides

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N Engl J Med 387(3):205216 [DOI] [PubMed] [Google Scholar] 24.Jastreboff AM, le Roux CW, Stefanski A, Aronne LJ, Halpern B, Wharton S, Wilding JPH, Perreault L, Zhang S, Battula R, Bunck MC, Ahmad NN, Jouravskaya I (2025) SURMOUNT-1 investigators

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The weight loss was augmented by the addition of GCGR-mediated increases in energy expenditure to GIPR- and GLP-1R-driven calorie intake reduction

No changes in electrocardiogram or worsening of liver or kidney function have been reported