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Often patients are able to lose more than that

Sleep deprivation impairs insulin secretion and glucose tolerance, contributing to T2DM risk [50]

Avoid large, fatty, or heavily processed meals immediately before or within two hours after injection, as these can amplify nausea and digestive discomfort

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Pharmacological alternatives may be appropriate for some patients

What to tell your rheumatologist If you are considering tirzepatide, bring this topic to your rheumatologist first