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Its receptor GLP-1R is mainly expressed in islet cells in the pancreas, and is also widely expressed in tissues such as stomach, small intestine, heart, kidney, lung and brain

doi: 10.1007/s00415-008-6001-2

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Further investigations showed that GLP-1R-mediated cAMP responses were reduced in islets extracted from these mice, suggesting that a high cholesterol diet specifically impacts on beta cell GLP-1R activity

For analysis of insulin, C-peptide, CCK, and total bile acids, blood was collected in dry tubes for coagulation (15 minutes at room temperature)

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