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BI 456906: discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy

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Recommendations: A Collaborative Approach If you are considering or currently taking a GLP-1 inhibitor, especially if you have a pre-existing mental health condition, open communication with both your prescribing physician and your mental health provider is paramount

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Covalent attachment of the GLP-1R agonist exendin-4 (Ex4) to dicyanocobinamide (Cbi), a corrin ring containing precursor of vitamin B12, produces a corrinated Ex4 construct (Cbi-Ex4)

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