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Description
Ten healthy volunteers with no previous history of drug or alcohol abuse received intravenous infusions of the GLP1 receptor agonist exenatide, while being in a SPECT scanner

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One potential limitation of this study is the observational design, which entails a risk of residual confounding

Clin Ther2009 Nov;31(11):2472-88

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The reason lies in how the drug interacts with the brains dopamine system, reward pathways, and neural circuitry responsible for motivation and reinforcement