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In a published Phase 2 trial (48 weeks), adults with obesity who took retatrutide lost, on average, more weight at higher doses, with the 12 mg group showing 24.2% average weight change at 48 weeks (compared with 2.1% in the placebo group)

Ghrelin Modulates Brain Activity in Areas that Control Appetitive Behavior

The neuroprotective potential of GLP-1RA semaglutide was shown in a rat model of hypertensive glaucoma

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This complementary action supports the bodys transition to a healthier inflammatory state

More research is needed on how GLP-1 RAs affect electrolyte balance (and its likely highly individual depending on each persons unique circumstances), but the topic deserves attention given hydrations role in metabolic health