shelf life of tirzepatide compound Tirzepatide / Niacinamide Injection Compounded versions of tirzepatide (Mounjaro,

How Mounjaro Might Promote Clot Formation: The Possible Mechanisms Several mechanisms could raise clot risk while using Mounjaro

RCT STEP 9 - Semaglutide vs Placebo for Knee Osteoarthritis in Patients with Obesity, NEJM (2024) [PubMed abstract] The STEP 9 study enrolled 407 patients with BMI 30 and a clinical and radiologic diagnosis of moderate knee osteoarthritis with at least moderate pain Main inclusion criteria Age 18 years or older BMI 30 ACR diagnostic criteria for knee OA Moderate X-ray changes (Kellgren-Lawrence grade 2 or 3) in target knee Knee OA WOMAC pain score of 40 Main exclusion criteria Use of opioid medications Use of obesity medication within 90 days Knee injection within 90 days Baseline characteristics Average age - 56 years Average weight - 239 lbs (108.6 kg) Average BMI - 40.3 Female sex - 82% Average WOMAC pain score - 70.9 Randomized treatment groups Group 1 (271 patients): Semaglutide 2.4 mg once weekly Group 2 (136 patients): Placebo Semaglutide was started at 0.24 mg once weekly and titrated over 16 weeks to 2.4 mg The percentage change in body weight and the change in the WOMAC pain score (scale 0 - 100, with higher scores meaning worse outcomes) from baseline to week 68 Primary outcome: Results Among participants with obesity and knee osteoarthritis with moderate-to-severe pain, treatment with once-weekly injectable semaglutide resulted in significantly greater reductions in body weight and pain related to knee osteoarthritis than placebo

32 In an open-label, substudy of patients with type 2 diabetes and NASH (n = 502), tirzepatide treatment resulted in a significant reduction in liver fat compared with insulin degludec after 52 weeks

Jamy Ard, MD, FTOS, can be reached at [email protected]

Medications Some diabetes and weight-loss medications list fatigue as a side effect

This was evidenced by increased CYP1A1, interleukin-10 (IL-10), and IL-22 levels that consequently alleviate metabolic syndrome and inflammation