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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), initially developed for the treatment of type 2 diabetes and obesity, may modulate pathways associated with the hallmarks of aging

A rise in the use of non-FDA-approved diabetes and obesity medications has spurred health care professionals and medical organizations to speak out about safety concerns.In December, the FDA released a statement to health care professionals and patients warning against the use of compounded and counterfeit versions of diabetes and obesity drugs, including semaglutide (Ozempic/Wegovy, Novo

But once that pharmacological scaffolding is gone, the old dynamics often roar backstronger than before.

Incretin-based therapies The year 2021 welcomed a game changer in the form of semaglutide for treatment of T2D in Singapore: Once-weekly subcutaneous (SC) semaglutide 1 mg (Ozempic®) and daily oral (PO) semaglutide (Rybelsus®)

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Ozempic face and facial aging have been observed as side effects in many patients after glucagon like peptide 1 receptor agonists (GLP-1RA) therapy for type 2 diabetes mellitus (T2DM) and obesity