do some people respond better to semaglutide than tirzepatide as Compared with for the Treatment of Obesity Tirzepatide vs. Semaglutide for Weight

10.1016/j.ijcard.2019.04.039 162

Dehydration is a common condition encountered in both acute and ambulatory care

Leptin transport across the BBB is impaired in obesity (Burguera et al., Hyperleptinemia, which either manifests gradually in association with age-related obesity or is produced rapidly by the consumption of energy-enriched diets, is associated with decreased brain leptin concentrations in rodents and humans (Banks et al., 2008

Small increases above a person's typical weekly routine (~30 min) showed little impact, but larger deviations were associated with elevated HR and persistently lower HRV suggesting recovery tolerance narrows after GLP initiation

These effects appear to reduce inflammatory markers such as C-reactive protein and interleukin-6, but there is no evidence that this affects vaccine efficacy

Diabetes in pregnancy: management from preconception to the postnatal period Recommendations (NG3)