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Restless legs syndrome (RLS) is a neurological disorder marked by symptoms of unpleasant sensations and an uncontrollable desire to move the legs.

Akkermansia muciniphila produces P9, a small protein that interacts with ICAM-2 to increase thermogenesis and glucagon-like peptide-1 (GLP-1) secretion in mice

Aging is the strongest risk factor for many chronic diseases, including frailty and neurodegenerative conditions

Symptoms are typically relapsing-remitting at first