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Across our case studies for these drugs, we observe the following trends: Patent Term Extensions: Statutory Patent Term Adjustment (PTA) and Patent Term Extension (PTE) mechanisms delay the entry of generic medicines and add billions in additional revenue for blockbuster 2 drugs, even before accounting for any extended market monopoly as a result of follow-on patenting

Cardiology in review , 22 (2), 5668

Use of semaglutide and risk of non-arteritic anterior ischemic optic neuropathy: A DanishNorwegian cohort study

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Cell 180 , 373386 (2020)

The constraint has migrated to the final, sterile, format-specific step and that step is harder to scale, slower to qualify, more exposed to a rising regulatory floor, and more dependent on scarce specialist talent than the upstream capacity ever was