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The half-life of a drug is the amount of time it takes for the concentration of that drug in your bloodstream to be reduced by exactly one-half (50%)

Treated mice exhibited reduced food intake, attenuated weight gain, and improved glucose metabolism and insulin sensitivity without detectable adverse effects

Obesity can lead to a multitude of acute and chronic physical and mental health issues

8,47 There is therefore an unmet need for an effective and safe pharmacological therapy for the management of overweight and obesity

Reporting helps improve the safety monitoring of medications

We have shown that deletion of Gadd45a leads to autistic traits and accompanying symptoms in the mouse model, including epilepsy phenotype