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Semaglutide increased MASH resolution without worsening fibrosis and significantly increased the proportion of individuals achieving 1-stage fibrosis improvement compared with placebo, with a clinically meaningful number needed to treat

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The drugs can also reduce the effectiveness of some forms of birth control, making unplanned pregnancies more likely.

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Headaches are reported by some patients taking semaglutide, though they are not among the most frequent side effects
