health benefits of glp 1 drugs GLP-1 & What They Do Stopping GLP-1s leads to rapid

These drugs have attracted significant attention in both medical communities and the general public

Depending on the medication, people can lose around 13%20% of their body weight with semaglutide (Wegovy, Ozempic, Saxenda) and 15%21% with tirzepatide (Zepbound, Mounjaro), on average

GLP-1R agonism has also been demonstrated to reduce BP in people with T2DM (as reviewed in [611,622,649])

Mollan SP, Wakerley BR, Alimajstorovic Z, Mitchell J, Ottridge R, Yiangou A, et al

On the other hand a GLP1-ANP axis has been only demonstrated in hypertensive mice, in which GLP-1R activation in the atria leads to ANP secretion and stimulation of natriuresis and vasodilation in the consequence

Higher efficacy Aside from pricing competition and label expansion, greater efficacy in HbA1c reduction and/or weight loss, reduced side-effects and increased patient convenience (eg an oral tablet rather than a subcutaneous injection) will also contribute to the success of new GLP-1s and associated weight loss medication