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Titration and tolerance affect the pace of results

The vascular benefits of GLP-1 use might explain any improvements

GLP-1 RA use was identified as an independent risk factor for food retention (OR 9.19, p = 0.0003)

GLP-1Rs are also present on Schwann cells and sensory, motor, and enteric neurons, implicating them in peripheral neuropathy and metabolic disease modulation [73]

Aigner, T., Haag, J., Martin, J

Elsewhere Nicolae Paulescu, a Romanian physiologist took advantage of enforced retirement in 1916 when German troops occupied Bucharest to develop an aqueous pancreatic extract which proved effective at lowering blood and urine sugar levels in dogs that previously had their pancreata removed