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Obesity is linked to several comorbidities, such as diabetes and heart failure

Cardiovascular Benefits Lowers the risk of major cardiovascular events (e.g., heart attack, stroke) in individuals with Type 2 diabetes existing heart disease
Secretion of adipokines by human adipose tissue in vivo: partitioning between capillary and lymphatic transport

doi: 10.1136/bmj-2023-076410 4

VESPER-2: glycemic control in type 2 diabetes VESPER-2 looked at weekly dosing in adults with obesity/overweight and type 2 diabetes, and Pfizer reports dose-dependent reductions in both body weight and HbA1c

Effect of the once-daily human GLP-1 analogue liraglutide on appetite, energy intake, energy expenditure and gastric emptying in type 2 diabetes