oral glp-1 agonists Anesthetic Considerations for Patients Taking Glucagon-Like Peptide-1 Oral Small-Molecule GLP-1 Receptor Agonists:

Kawatani, M

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in Spain, its current prevalence ranges between 2833%11,12 and it is a recognized as a cardiovascular risk factor and increases the mortality in this population.1315 Furthermore, in patients with DM2 and advanced CKD there are limitations in the prescription of certain antihyperglycemic drugs (e.g., metformin or sulfonylureas) and there is an increased risk of hypoglycemia with antihyperglycemic treatment,16 a complication that is associated with increased cardiovascular risk17 and hinders the achievement of glycemic control targets

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These are averages, meaning some individuals exceed them substantially

Upon AGEs binding to their receptor (RAGE), the activation of NF-B occurs, leading to an increase in inflammatory cytokines and oxidative stress [55]