glp-1 weight loss drug news today 2025 Market Size, Share GLP-1 Pipeline Update: August 2025

Exendin-4 reduces ischemic brain injury in normal and aged type 2 diabetic mice and promotes microglial M2 polarization

Hughes S, Neumiller JJ

In November 2015, Sheu and colleagues [13] showed that omarigliptin could be used once-weekly and was generally well tolerated throughout the base and extension studies) Evogliptin (approved as Suganon/Evodine for use in South Korea) [14] Gosogliptin (approved as Saterex for use in Russia) [15] Dutogliptin (PHX- 1149

Previous meta-analyses have indicated that tirzepatide might potentially decrease the risk of cardiovascular events by affecting cardiac cells, the pancreas, and other tissues directly and indirectly [2]

This may suggest that the observation of a benefit of the GLP-1 RAs on heart failure hospitalisation as found in the meta-analysis by Sattar and colleagues is driven by data from AMPLITUDE-O and Harmony Outcomes

Available from: Bawa T, Dhingra V, Malhotra N, Wasir JS, Mithal A