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Inadequate response to Wegovy

Ranking of these genes shows 15 main genetic mechanisms driving efficacy: Genetic contributions identified included leptin, dopamine, glutamate, PI3K-AKT, and histamine mediated signaling as well as other mechanisms Modulating motivation and rewards-based feeding, appetite regulation (positive and negative), energy balance, and glucose homeostasis Drivers of strong responses to GLP-1A drugs were also associated with insulin secretion, lipid metabolism, type-II diabetes risk, cardiac function, fatty acid oxidation, adipocyte differentiation, and obesity The biomarkers were identified in 100% of the patients

43 In a phase 3 trial including patients with obesity (excluding T2DM), the highest dose group achieved a mean weight reduction of 11.2% by week 72

The compound is administered as a subcutaneous injection once weekly, similar to Semaglutide and Tirzepatide

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Whether the B12 addition justifies the cost depends on your individual needs