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The questionnaire was delivered in Japanese and was ideally answered before any other trial-related activities
Of note, the dopamine neurons in the ARH also regulate pituitary hormones (71), which could be linked to the GLP-1 stimulatory release of pituitary hormones, such as vasopressin and corticotropin-releasing hormone (72)

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Moreover, these ligands can be spontaneously embedded in the phospholipid layer of lipid carriers using a plug-and-play approach without chemical modification, with excellent tunability and immunocompatibility

These demographic pressures are two-fold: (i) the inevitable ageing of populations increases demands for health services, and (ii) fertility decline leads to a relative decline in the size of the working age population, with its attendant implications for the capacity to finance and provide health services
