glp 1 agonists and sglt2 inhibitors Cardiorenal Protection: Potential of GLP-1 Receptor in the Treatment of Type 2 Diabetes | Diabetes Therapy Blood pressure effects of SGLT2
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Put plainly, when theres less body weight to maintain, the body does less work but it also becomes extra efficient, burning fewer calories than predicted and nudging weight back up

10.1038/sj.mp.4002133 207

The hormone also decreases the parietal cells secretion of gastrin and stomach acid, proliferates the bones osteoblasts and inhibits osteoclasts, and may be involved in neuro-signaling as evidenced by widespread expression of GIPr in the brain

DAlessio D, Hring HU, Charbonnel B

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