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These processes are thought to be associated with the increased muscular SOCS3 and PTP1B and the weakened JAK2-STAT3, AMPK, IGF-1 and GLUT4 signaling [226, 229], [230], [231], [232]
Other less common side effects can include pancreatitis, gastroparesis, bowel obstruction, gallstones, blockage of the bile duct and risk of acute kidney injury
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The GIPR rs1800437 variant affects glucose-dependent insulinotropic polypeptide signaling, which works synergistically with GLP-1 to regulate glucose homeostasis
